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Home > VITAFRIENDSPKU > PKU JOURNEY > ALL PRODUCTS > PKU sphere<sup>®</sup> liquid

PKU sphere liquid is a GMP-based ready-to-drink protein substitute containing 20g PE

PKU sphere®20 liquid

What is PKU sphere®20 liquid?

PKU sphere20 liquid is a low phenylalanine (Phe), ready to drink protein substitute which is based on glycomacropeptide (GMP for short). It’s low in volume containing 20g of protein in 237mls and it’s easy to use. Simply, shake the bottle, open and drink. You can reseal afterwards if you don’t drink it all at once. 

PKU sphere20 liquid contains:

  • the equivalent of 20 grams of protein
  • 30mg of Phe
  • 120 calories

PKU sphere20 liquid contains a range of vitamins, minerals and DHA (an essential fat) which are typically found in high protein foods such as meat, fish or eggs. These types of foods are restricted in a PKU diet and therefore vitamins, minerals and DHA are added to PKU sphere20 liquid to help meet your daily nutritional requirements.

What makes PKU sphere20 liquid different to some other protein substitutes?

The big difference is that PKU sphere20 liquid is based on GMP from a natural protein source. It contains a blend of GMP and some amino acids, whereas most other protein substitutes are based just on amino acids.

Who is PKU sphere20 liquid for?

PKU sphere20 liquid is for children and adults with PKU. It is suitable from 3 years of age onwards and can be taken throughout adulthood. PKU sphere20 liquid, like all GMP‐based protein substitutes contains a small amount of Phenylalanine (Phe), therefore, your dietitian will advise if it is suitable for you or your child to try.

How much PKU sphere20 liquid do I need?

The amount of PKU sphere20 liquid needed will depend on a variety of factors including age and weight. Your dietitian will advise exactly how much PKU sphere20 liquid will be needed each day.

How do I take PKU sphere20 liquid?

It’s really easy. Firstly, give the bottle a good shake. Then twist the lid to open the bottle and drink. You can reseal the bottle if you don’t finish it all at once and consume it within 4 hours at room temperature or within 24 hours if refrigerated. Shake well again before drinking.

What flavour is PKU sphere20 liquid?

PKU sphere20 liquid is now available in two flavours:  

- Vanilla 

- Chocolate 

I prefer to take a powdered product, what are my options?

PKU sphere20 liquid also has a powdered version. The powder version is available in two pack sizes, one containing 20 grams of protein and the other containing 15. PKU sphere15 and 20 powder can easily be mixed in a sphere sports shaker and look just like a shake you’d see someone sipping in the gym! PKU sphere15 is available in vanilla, red berry and chocolate flavour and PKU sphere20 gives you the additional flavour options of lemon and banana too.


PKU sphere is currently being used by lots of people. Vitaflo carried out a short survey to understand more about the experience of PKU sphere users. You can find out more by watching this short video.



PKU sphere20 liquid is a Food for Special Medical Purposes for use in the dietary management of PKU from 3 years of age. PKU sphere20 liquid should be used under Medical Supervision. For further information speak to your Healthcare Professional.

Explorers Club

If you haven’t done so already, why not register for the Vitafriends Explorers Club – an education programme for families managing PKU in the early years.

It’s packed full of recipes to help with the introduction of solid foods!